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KMID : 0377519880130010031
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Chung-Ang Journal of Medicine
1988 Volume.13 No. 1 p.31 ~ p.43
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Lethal Dose and Effects of Cadmium on Blood and Liver in Acute Cadmium Intoxication
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Abstract
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Cadmium toxicity on lethality and hepatotoxicity in relation to dosage was investigated with Sprague-Dawley rats after single dose of 0.1- 0.3% cadmium chloride solutions into peritoneal cavity of each rats. The rats were divided into 7 groups and amount of dose ranged from 1 to 32 mgCd/kg body weight.
Lethal dose (LDso) was calculated by probit method, and found to be 5.71 mgCd/kg body weight. In contrast to an average concentration of cadmium in blood for control group was 0.028+ 0.095 gCd/ 1, the blood concentration for a group to which 1 mgCd/kg body weight was given increased to 15.0 3.9 gCd/ 1, and fitting the blood concentrations to power function curve on dosage. Cadmium concentrations in hepatic tissue had also the same relationship as blood cadmium concentrations and, in turn, between blood and hepatic concentrations with regression coefficient of 0.707.
Minimal toxic dose (TDLo) based on histopathological findings during the course of observation after the dose was revealed to be 2.0 mgCd/kg body weight and the effective dose (EDso) for inducing inflammatory cell infiltration (Li group) and for induction of pyknosis, hyperchromaticity or partial necrosis of hepatic cells (L2 group) were identical with a value of 3.29 mgCd/kg body weight.
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